Mucoepidermoid Carcinoma-Histopathologist Perspective– A Review


  • Mahesh Babu T T
  • Sunil Kumar Kothawar
  • Malathi N
  • Namrata Patil


Mucoepidermoid carcinoma is the most common malignancy of the salivary glands. It comprises 5-10% of all salivary gland tumours. It is histologically comprised of a mixture of mucous cells, intermediate cells, squamoid or epidermoid cells. This tumour may also demonstrate clear cell, oncocytic or columnar cells. There is arguably no other salivary gland tumour in which grading is as important to prognosis and therapy.

Here we present a review with systematic approach to the histopathologic diagnosis, grading and prognosis, with a special emphasis on the biologic potential based on newer investigative modalities from the histopathologist perspective.


Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. (2001). 25(7):835-45.

Seethala RR. An update on grading of salivary gland carcinomas. Head Neck Pathol. (2009). 3(1):69-77.

Castro EB, Huvos AG, Strong EW. Foote F. Tumors of the major salivary glands in children. Cancer (1972). 29:312-7.

Krolls SO, Trodahl JN, Boyers RC. Salivary gland lesions in children: a survey of 430 cases. Cancer (1972). 30:459-69.

Seifert G, Okabe H, Caselitz J. Epithelial salivary gland tumors in children and adolescents: analysis of 80 cases (salivary gland registry 1965-1984). ORL J Otorhinolaryngol Relat Spec (1986). 48:137-49.

Stewart FW, Foote FW, Becker WF. Muco-epidermoid tumors of salivary glands. Ann Surg (1945). 122(5):820- 844.

Simon D, Somanathan T, Ramdas K, Pandey M. Central mucoepidermoid carcinoma of mandible - a case report and review of the literature. World J Surg Oncol- (2003). 1(1):1.

Seifert G, Sobin LH. Histological typing of salivary gland tumours. In; International classification of tumours. New York: Springer-Verlag; (1991).

Cawson RA, Gleeson MJ, Eveson JW. The Pathology and Surgery of the Salivary Glands. Oxford: ISIS Medical Media. (1997). 117-69.

Ellis GL, Auclair PL. Atlas of tumor pathology, tumors of the salivary glands, series 3, fascicle 17. Washington, DC: Armed Forces Institute of Pathology. (1996). 155- 75, 353-5.

Spi ro RH, Huvos AG, Berk R. St rong EW. Mucoepidermoid carcinoma of salivary origin: a clinicopathologic study of 367 cases. Am J Surg (1978). 136:461-8.

Waldron CA, El-Mofty SK, Gnepp DR. Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1988). 66:323-33.

Seifer t G. Oralpathologie I: Pathologie der Speicheldrusen. Berlin: Springer-Verlag (1996). 503, 527-50.

Brookstone MS, Huvos AG. Central salivary gland tumors of the maxilla and mandible: a clinicopathologic study of 11 cases with an analysis of the literature. J Oral Maxillofac Surg (1992). 50:229-36.

Noda S, Sundaresan S, Mendeloff EN. Tracheal mucoepidermoid carcinoma in a 7-year-old child. Ann Thorac Surg (1998). 66:928-9.

Wedell B, Burian P, Dahlenfors R. Cytogenetic observations in a mucoepidermoid carcinoma arising from heterotopic intranodal salivary gland tissue. Oncol Rep (1997). ;4:515-6.

Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer (1998). 82(7):1217-24.

Batsakis JG, Luna MA. Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol. (1990). 99(10 Pt 1):835-8.

Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A. Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes. Acta Otolaryngol. (2002). 122(7):758-64.

Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, et al. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer (2008). 113(8):2082-9.

Pinto AE, Fonseca I, Martins C, Soares J. Objective biologic parameters and their clinical relevance in assessing salivary gland neoplasms. Adv Anat Pathol (2000).7:294-306.

Zarbo RJ. Salivary gland neoplasia: a review for the practicing pathologist. Mod Pathol. (2002). 15(3):298- 323.

Alves FA, Pires FR, De Almeida OP, Lopes MA, Kowalski LP. PCNA, ki-67 and p53 expressions in submandibular salivary gland tumours. Int J Oral Maxillofac Surg (2004). 33:593-7.

Ben-Izhak O, Laster Z, Araidy S, Nagler RM. TUNEL-an efficient prognosis predictor of salivary malignancies. Br J Cancer (2007). 96:1101-6.

Etemad-Moghadam S, Baghaee F, Tirgary F, Motahhary P, Khalili M, Esghyar N et al. Expression of p21WAF in salivary gland mucoepidermoid carcinoma and its relation to histologic grade. Int J Surg Pathol (2007). 15:6-13.

Teixeira MR. Recurrent fusion oncogenes in carcinomas. Crit Rev Oncog (2006). 12:257-71.






Review Article