Caries Vaccine – A Review


  • Sujith R
  • Sachin Naik
  • Janavathi J
  • Rajanikanth P


Streptococcus mutans play a key role for the development of dental caries and that a vaccine directed against this microorganism could be a valuable adjunct to existing preventive measures in some countries. Only a few studies, however, have examined the efficacy of dental caries vaccines in humans. Although several years have passed, active immunization against caries remains a goal yet to be achieved. The successful development of vaccines against oral diseases requires a concerted effort by industry, government, and academia and also it is a matter of great importance to ensure safety along with effective protection.


Shafer’s text book of oral pathology. 5th ed.

Russell MW, Childers NK, Michalek SM, Smith DJ, Taubman MA. A caries vaccine? The state of the science of immunization against dental caries. Caries Res (2004). 38(3): 230–35.

Hajishengallis, M. Current status of a mucosal vaccine against dental caries. Oral Microbiol Immunol (1999). 14(1): 1–20.

Park’s text book of preventive and social medicine. 20th ed.

Question of the month. JADA (1998). 129: 682.

Smith DJ. Caries vaccines for the twenty-first century. J Dental Educ Vol. 67(1).

Mandel ID. Caries prevention: current strategies, new directions. Am Dent Assoc (1996). 127(10): 1477–88.

Hajishengallis G, Michalek SM, Russell MW. Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin. Infect Immun (1996). 64(2): 665–67.

Childers NK,Tong G, Mitchell S, Kirk K, Russell MW, Michalek SM A controlled clinical study of the effect of nasal immunization with a Streptococcus mutans antigen alone or incorporated into liposomes on induction of immune responses. Infect Immun (1999). 67(2): 618–23.

Redman TK, Harmon CC, Lallone RL, Michalek SM Oral immunization with recombinant Salmonella typhimurium expressing surface protein antigen A of Streptococcus sobrinus: dose response and induction of protective humoral responses in rats Tamara k. Infect Immun (1995). 63(5): 2004–2011.

Niu Y, Sun J, Fan M, Xu QA, Guo J, Jia R, et al. Construction of a new fusion anti-caries DNA vaccine. J Dent Res (2009). 88(5): 455–60.

Shivakumar KM, Vidya SK, Chandu GN. Dental caries vaccine. Indian J Dent Res (2009). 20(1): 99–106.

Abiko Y. Passive immunization against dental caries and periodontal disease: development of recombinant and human monoclonal antibodies. Crit Rev Oral Biol Med (2000).11(2): 140–58.

Fontana M, Dunipace AJ, Stookey GK, Gregory R. Intranasal immunization against dental caries with a Streptococcus mutans-enriched fimbrial preparation. Clin Diagn Lab Immunol (1999). 6(3): 405–409.






Review Article