Urinary Bladder: Primitive Neuroectodermal Tumour/Ewing’s Tumour – A Rare Case
We hereby report a rare case of primary primitive neuroectodermal tumour (PNET)/Ewing’s tumour of the urinary bladder. Primary PNETs of the bladder are very aggressive neoplasms. They are extremely rare and only 12, as on July 2014, have been reported in the literature. A young 22-year old male patient, agricultural labourer by occupation, presented with complaints of urinary obstruction and haematuria of 1-month duration. A provisional diagnosis of small round cell tumour was considered on examination of the biopsy specimen. Subsequently, the panel of immunohistochemical markers CD-99, NSE, LCA, Desmin and vimentin were performed and finally reported as urinary bladder – PNET/Ewing’s tumour – CD-99+.
De Alava E, Pardo J. Ewing tumor: tumor biology and clinical applications. Int J Surg Pathol 2001;9:7–17. PMid:11469351http://dx.doi.org/10.1177/10668969010 0900104
Katchy KC, Ziad F, Alexander S, Gad H, Abdel Mota’alM. Malignant bone tumors in Kuwait. A 10-year clinicopathological study. Int Orthop 2005;29:406–11.
Kempson RL, Fletcher CDM, Evans HL, Hendrickson MR, Sibley RK: Peripheral primitive neuroectodermal tumor/Ewing’s sarcoma family of tumors. In: Rosai J, editor. Tumors of the soft tissues. Washington, DC: Armed Forces Institute of Pathology 2001;444–52.
Amiel A, Ohali A, Fejgin M, Sardos Albertini F, Bouaron N, Cohen IJ, et al. Molecular cytogenetic parameters in Ewingsarcoma. Cancer Genet Cytogenet
Ellinger J, Bastian PJ, Hauser S, Biermann K, Muller SC. Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies. Urology 2006;68:257–62.
Lopez-Beltran A, Perez-Seoane C, Montironi R, Hernandez-Iglesias T, Mackintosh C, de Alava E. Primary primitive neuroectodermal tumor of the urinary bladder: a clinico-pathological study emphasising immunohistochemical, ultrastructural and molecular analyses. J Clin Pathol 2006;59:775–8.
Kruger S, Schmidt H, Kausch I, Bohle A, Holzhausen HJ, Johannisson R, Feller AC. Primitive neuroectodermal tumor (PNET) of the urinary bladder. Pathol Res Pract 2003;199:751–4.
Friedrichs N, Vorreuther R, Poremba C, Schafer KL, Böcking A, Buettner R, Zhou H. Primitive neuroectodermal tumor (PNET) in the differential diagnosis of malignant kidney tumors. Pathol Res Pract 2002;198:563–9.
Kumar V, Khurana N, Rathi AK, Malhotra A, Sharma K, Abhishek A, Bahadur AK. Primitive neuroectodermal tumor of prostate. Indian J Pathol Microbiol 2008;51:386–8.
Dastidar AG, Chakrobarty A, Sadhukhan S Halder A, Basuini. Primitive neuroectodermal tumor urinary bladder: A rare case report and review of literature. Clin Cancer Investig J 2014;3:162–4.
Fletcher CD. Peripheral neuroectodermal tumors. In: Franz ME, Weiss SW, editors. Soft tissue tumors. 3rd ed. St. Louis: Mosby Co; 1995. pp. 1221–50.
Ishii N, Hiraga H, Sawamura Y, Shinohe Y, Nagashima K. Alternative EWSFLI1 fusion gene and MIC2 expression in peripheral and central primitive neuroectodermal tumors. Neuropathology 2001;21:40–4.
Desai S. Primary primitive neuroectodermal tumour of the urinary bladder. Histopathology 1998;12:477–8.
Banerjee SS, Eyden BP, McVey RJ, Bryden AA, Clarke NW. Primary peripheral primitive neuroectodermal tumour of the urinary bladder. Histopathology 1997;30:486–90.
Mentzel T, Flaschka J, Mentzel HJ, Eschholz G,Katenkamp D. Primary primitive neuroectodermal tumor of the urinary bladder. Clinicopathologic case report and differential small cell tumor diagnosis of this site. Pathologe 1998;19:154–8