Myofibroblasts in Epithelial Mesenchymal Transition and its Clinical Significance

Authors

  • Diksha Singh King George Medical University, Lucknow
  • Anand Tegginamani Hitkarni Dental College, Jabalpur, MP
  • Manish Kumar Singh BRD Medical College, Gorakhpur, UP
  • Fahad M Samadi King George Medical University, Lucknow
  • Parikshit Sharma King George Medical University, Lucknow
  • Akhilesh Diwedi Banaras Hindu University, Varanasi

Abstract

Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete (scar formation) but the functionality of the tissue is only rarely perfectly restored. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. These diverse cell types probably contribute to the appearance of myofibroblast subpopulations which show specific biological properties and which are important to understand in order to develop new therapeutic strategies for treatment of fibrotic and scarring diseases.

Key words:  Myofibroblasts, EMT, TNF, Micrenvironment.

Author Biographies

Diksha Singh, King George Medical University, Lucknow

Assistant professor

Anand Tegginamani, Hitkarni Dental College, Jabalpur, MP

Professor

Manish Kumar Singh, BRD Medical College, Gorakhpur, UP

Assistant Professor

Fahad M Samadi, King George Medical University, Lucknow

Lecturer

Akhilesh Diwedi, Banaras Hindu University, Varanasi

Senior Resident

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Published

2014-06-21

Issue

Section

Review Article