Dental Stem Cells- The New Era of Dentistry


  • Sunitha B
  • Subashchander K


Tissue engineering is a science based on the fundamental principles involving the identification of appropriate cells, the development of conductive scaffolds and the understanding of the morphogenic signals required to induce cells to regenerate a tissue or an organ (Karien, 2009). Stem cells are one of the most fascinating areas of biology today. They are the key elements for tissue engineering. For years, scientists all over the world have been working on the possibilities of using the stem cells to regenerate human cells that are damaged due to illness, developmental defects and accidents. The discovery of dental stem cells and the recent advances in cellular and molecular biology have led to the development of novel therapeutic strategies that aim at regeneration of oral tissues that were injured by disease or trauma.


Suardita K. The potential application of stem cell in dentistry. Dent J (Maj Ked Gigi) (2006). 39(4):177-80.

Karien GA. Dental pulp stem cells, a new era in tissue engineering. Smile Dent J (2009). 4(2-5).

Vanishree N, Chaithra V, Pabbia A. A tooth for a tooth: dental stem cell banking in India. Ann Essences Dent (2011). III Issue (4-7).

Krebsach PH, Robey PG. Dental and skeletal stem cells: Potential cellular therapeutics for craniofacial regeneration. J Dent Educ (2002). 6:766-73.

Arora V, Arora P, Munshi AK. Banking stem cells from human exfoliated deciduous teeth (SHED): Saving for the future. J Clin Pediatr Dent 92009). 33:289-94.

Krasner P, Verlander P. Stem cells in dentistry and medicine: The dentist’s role (2011). Available at http://

Mao JJ, Giannobile WV. Helms JA, Hollister SJ, Krebsbach PH. Craniofacial tissue engineering by stem cells. J Dent Res (2006). 85(11):966-79.

Buurma B, Gu K, Rutherford RB. Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. Eur J Oral Sci (1999). 107:282-9.

Huang GT, Sonoyama W, Chen J, Park SH. In vitro characterization of human dental pulp cells: Various isolation methods and culturing environments. Cell Tissue Res (2006). 324:225-36.

Marion NW, Mao JJ. Mesenchymal stem cells and tissue engineering. Methods Enzymol (2006). 420:339-61.

Mao JJ, Vunjak-Novakovic G, Mikos AG, Atala A. Translational approaches in tissue engineering and regenerative medicine. Boston and London:Artech House; (2007). pp. 12-14.

Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH. Craniofacial tissue engineering by stem cells. J Dent Res (2006). 85(11):966-79.

Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res (2005). 84(10):907-12.

Alhadlaq A, Mao JJ. Tissue engineered osteochondral constructs in the shape of an articular condyle. J Bone Joint Surg Am (2005). 87:936-44.

Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, et al. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res (2002). 81(10):695-700.






Review Article