A Case of Macrocytic Anaemia with Paraplegia due to Tuberculosis
A case of macrocytic anaemia with tuberculosis and paraplegia is very rare. This paper discusses the case of a patient who presented with fever and paraplegia, duly diagnosed as spinal tuberculosis, and showed considerable improvement with anti-tubercular regimen and treatment with vitamin B12.
Zschocke J, Schindler S, Hoffmann GF, Albani M. Nature and nurture in vitamin B12 deficiency. Arch Dis Child (2002). 87:75-6.
Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharm (1993). 241(1):1-6.
McKee LC Jr. Fever in megaloblastic anemia. Med J (1979). 72(11):1423-4.
Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol (2006). 5(11):949-60.
Hendel J, Dam M, Gram L, Winkel P, Jørgensen I. The effects of carbamazepine and valproate on folate metabolism in man.
Nutritional depletion as a side effect of anticonvulsant medications. Learning discoveries psychological services. Available from: http://www.learningdiscoveries.org/ ideEffectsofAnticonvulsantMedications.htm
Schwaninger M, Ringleb P, Winter R, Kohl B, Fiehn W, Rieser PA, et al. Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia (1999). 40:345-50.
Babior BM, Bunn HF. Megaloblastic anemias. In: Kasper L, Braunnwald E, Facci A, Hauser S, Longo D, Jameson J, editors. Harrison’s principles of internal medicine. 16th edition. United State of America: McGraw-Hill; (2005). pp. 601-7.
This work is licensed under a Creative Commons Attribution 3.0 License.
Print ISSN: 2347-6192
Online ISSN: 2347-6206